| | Day | Time | | Opponent | Score | | | Record |
| February |
| | 13 | 12:00PM | @ | Patten University | W-9-2 | | | 1-0 |
| | Game will be played at Standley Field - Hayward. |
| | | 2:00PM | @ | Patten University | W-4-2 | | | 2-0 |
| | Game will be played at Standley Field - Hayward. |
| | 15 | 12:00PM | vs. | Point Loma Nazarene University | L-1-10 | recap | | 2-1 |
| | Game will be played at CSU, East Bay |
| | | 2:00PM | vs. | Point Loma Nazarene University | L-3-4 (8) | recap | | 2-2 |
| | Game will be played at CSU, East Bay |
| | 19 | 12:00PM | vs. | California State University-San Marcos | L-2-8 | | | 2-3 |
| | Southern California Smash Tournament @ California Baptist University |
| | | 5:00PM | @ | California Baptist University | L-0-14 | | | 2-4 |
| | Southern California Smash Tournament @ California Baptist University |
| | 20 | 12:00PM | vs. | California State University-San Marcos | L-0-14 | | | 2-5 |
| | Southern California Smash Tournament @ California Baptist University |
| | | 2:30PM | @ | California Baptist University | L-1-9 | | | 2-6 |
| | Southern California Smash Tournament @ California Baptist University |
| | 21 | 11:00AM | @ | Concordia University | L-0-2 | | | 2-7 |
| | | 1:00PM | @ | Concordia University | L-0-12 | | | 2-8 |
| | 25 | 4:00PM | @ | Southern Oregon University | L-0-1 | | | 2-9 |
| | SOU Tournament - US Cellular Fields - Field 1 |
| | 26 | 9:00AM | @ | Concordia University | L-1-3 | | | 2-10 |
| | SOU Tournament - US Cellular Fields - Field 3 |
| | | 11:00AM | vs. | Oregon Institute of Technology | L-3-5 | | | 2-11 |
| | SOU Tournament - US Cellular Fields - Field 2 |
| | | 3:00PM | @ | Biola University | L-2-6 | | | 2-12 |
| | SOU Tournament - US Cellular Fields - Field 1 |
| | 27 | 11:00AM | @ | Northwest Christian University | L-10-11 | | | 2-13 |
| | SOU Tournament - US Cellular Fields - Field 4 |
| | | 1:00PM | @ | Southern Oregon University | L-8-11 | | | 2-14 |
| | SOU Tournament - US Cellular Fields - Field 1 |
| March |
| | 3 | 3:00PM | @ | Academy of Art University | RAIN | | | |
| | Cancelled - Rained out |
| | | 5:00PM | @ | Academy of Art University | RAIN | | | |
| | 9 | 10:00AM | vs. | Penn State Abington | W-16-0 | | | 3-14 |
| | Sun West Tournament - Hart Park Field #3 |
| | | 2:00PM | vs. | Concordia Illinois | W-8-0 | | | 4-14 |
| | Sun West Tournament - Hart Field Park #2 |
| | 10 | 10:00AM | vs. | Penn State Abington | W-15-0 | | | 5-14 |
| | Sun West Tournament - Hart Park Field #2 |
| | | 12:00PM | vs. | DeSales University | W-4-3 | | | 6-14 |
| | Sun West Tournament - Hart Park Field #2 |
| | 11 | 12:00PM | vs. | Wheaton College | W-3-1 | | | 7-14 |
| | Sun West Tournament - Hart Park Field #2 |
| | | 2:00PM | vs. | Chapman University | W-7-6 | | | 8-14 |
| | Sun West Tournament - Hart Park Field #3 |
| | 12 | 10:00AM | vs. | DeSales University | L-5-6 (8) | | | 8-15 |
| | Sun West Tournament - Hart Park Field #3 |
| | | 2:00PM | vs. | Suffolk University | W-11-1 | | | 9-15 |
| | Sun West Tournament - Hart Park Field #2 |
| | 17 | 6:00PM | vs. | William Jessup University | RAIN | | | |
| | Game will be played @ Thrasher Park in San Leandro |
| | | 8:00PM | vs. | William Jessup University | RAIN | | | |
| | Game will be played @ Thrasher Park in San Leandro |
| * | 20 | 12:00PM | @ | Bethany University | W-17-0 | | | 10-15 1-0 |
| * | | 2:00PM | @ | Bethany University | W-6-2 | recap | | 11-15 2-0 |
| * | 21 | 12:00PM | vs. | Menlo College | W-10-0 | | | 12-15 3-0 |
| | Game will be played @ Thrasher Park in San Leandro |
| * | | 2:00PM | vs. | Menlo College | W-5-0 | recap | | 13-15 4-0 |
| | Game will be played @ Thrasher Park in San Leandro |
| * | 27 | 12:00PM | vs. | Simpson University | L-1-3 | | | 13-16 4-1 |
| | Game will be played @ Thrasher Park in San Leandro |
| * | | 2:00PM | vs. | Simpson University | L-0-2 | recap | | 13-17 4-2 |
| | Game will be played @ Thrasher Park in San Leandro |
| April |
| * | 2 | 12:00PM | vs. | University of Great Falls | RAIN | | | |
| | Game will be played @ Thrasher Park in San Leandro |
| * | | 2:00PM | vs. | University of Great Falls | RAIN | | | |
| | Game will be played @ Thrasher Park in San Leandro |
| * | 7 | 4:00PM | vs. | William Jessup University | W-3-2 (9) | | | 14-17 5-2 |
| | Game will be played @ Thrasher Park in San Leandro |
| * | | Game 2 | vs. | William Jessup University | W-6-2 | | | 15-17 6-2 |
| | 10 | 1:00PM | vs. | Patten University | W-4-1 | | | 16-17 |
| | Game will be played @ Thrasher Park in San Leandro |
| | | 3:00PM | vs. | Patten University | W-7-2 | | | 17-17 |
| | Game will be played @ Thrasher Park in San Leandro |
| | 14 | 1:00PM | @ | Academy of Art University | L-3-4 (8) | | | 17-18 |
| | | Game 2 | @ | Academy of Art University | W-2-1 | | | 18-18 |
| * | 17 | 12:00PM | @ | Menlo College | W-8-0 | recap | | 19-18 7-2 |
| * | | 2:00PM | @ | Menlo College | W-6-1 | recap | | 20-18 8-2 |
| * | 18 | 12:00PM | vs. | Bethany University | W-3-0 | recap | | 21-18 9-2 |
| | Game will be played @ Thrasher Park in San Leandro |
| * | | 2:00PM | vs. | Bethany University | W-5-3 | recap | | 22-18 10-2 |
| | Game will be played @ Thrasher Park in San Leandro |
| * | 24 | 2:00PM | @ | William Jessup University | W-2-0 (8) | | | 23-18 11-2 |
| * | | 4:00PM | @ | William Jessup University | L-0-5 | | | 23-19 11-3 |
| * | 25 | 2:00PM | @ | Simpson University | W-6-1 | | | 24-19 12-3 |
| * | | 4:00PM | @ | Simpson University | L-5-6 | | | 24-20 12-4 |
| | 30 | 1:00PM | vs. | University of Great Falls | W-6-3 | recap | | 25-20 |
| | Game played at Simpson Softball Field |
| | | 4:00PM | @ | Simpson University | W-1-0 | recap | | 26-20 |
| | Simpson Softball Fields |
| May |
| | 1 | 2:00PM | @ | Simpson University | W-4-1 | | | 27-20 |
| | Holy Names Earns Bid to 2010 National Softball Tournament |
| | 20 | 9:00AM | vs. | Olivet Nazarene University | L-3-9 | recap | | 27-21 |
| | National Tournament, pool play opener |
| | 22 | 10:30AM | vs. | California Baptist University | L-5-13 | recap | | 27-22 |
| | Game will be played on field 2 |
| | 24 | 11:30AM | vs. | Midland University | W-1-0 | recap | | 28-22 |
| | Game will be played on field 3 |
